Carlos Ernesto Castro

This paper introduces Free Energy Spectroscopy (FES) to characterize chromatin compaction by analyzing end-to-end distance and nucleosome stacking interactions, revealing three mechanisms by which linker histones reshape compaction energetics.

This paper introduces a method to isolate ssDNA from dsDNA sources for DNA origami assembly, demonstrating its effectiveness across various dsDNA types and lengths.

This paper introduces a DNA origami-based sensor (NanoDyn) capable of detecting Na+ ion gradients across multiple spatial scales, demonstrating tunable sensitivity and resolution.

This paper introduces methods to recycle DNA components in DNA origami manufacturing, demonstrating the reprogramming of nanostructures and recovery of staple strands to create sustainable, reusable devices.

This paper uses molecular dynamics simulations to analyze how design parameters affect the mechanical properties of three types of molecular force sensors.

This study demonstrates the delivery of DNA origami nanorods into live cell nuclei using an antibody against RNA Polymerase II, showing structural integrity and sub-diffusive motion within the nucleus.