Ruo-Wen Chen

This study investigates how EWSR1::FLI1 binds to nucleosomes and DNA motifs, revealing its pioneer factor properties and preference for GGAA repeats.

The paper shows that cohesin facilitates nucleosome invasion by transcription factors, even in the absence of chromatin remodeling or replication.

This paper introduces Free Energy Spectroscopy (FES) to characterize chromatin compaction by analyzing end-to-end distance and nucleosome stacking interactions, revealing three mechanisms by which linker histones reshape compaction energetics.

This paper introduces a method to isolate ssDNA from dsDNA sources for DNA origami assembly, demonstrating its effectiveness across various dsDNA types and lengths.

The paper characterizes native nucleosome-positioning elements in yeast and shows they can be used to study nucleosome repositioning by transcription factors and chromatin remodelers.