Molecular basis of promiscuous chemokine-engagement by the Duffy antigen receptor
Manisankar Ganguly, Yuma Matsuzaki, Nabarun Roy, Divyanshu Tiwari, Sameer S. Kulkarni, Annu Dalal, Manish Kumar Yadav, Nilanjana Banerjee, Sudha Mishra, Kazuhiro Sawada, Kana M. Hashimoto, Kohei Yamaguchi, Martin J. Stone, Richard J. Payne, Andy Chevigné, , Arun K. Shukla
This study determines the cryo-EM structures of DARC bound to chemokines CCL7 and CXCL8, revealing unique binding mechanisms and the role of tyrosine sulfation and allelic variation in chemokine engagement.
bioRxiv · Mar 10, 2026 · PreprintBiochemistry