Martin J. Stone

The paper maps the chemokine-stimulated signal transduction network in monocytic cells and shows that chemotaxis emerges from a divergent signaling network that can be inhibited to block cell migration.

This study determines the cryo-EM structures of DARC bound to chemokines CCL7 and CXCL8, revealing unique binding mechanisms and the role of tyrosine sulfation and allelic variation in chemokine engagement.

The paper investigates whether CCR8 is a high-affinity receptor for CCL18 and finds that CCR8 does not respond to CCL18 in multiple assays.