Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus
Fumikazu Sano, Eiji Shigetomi, Youichi Shinozaki, Haruka Tsuzukiyama, Kozo Saito, Katsuhiko Mikoshiba, Hiroshi Horiuchi, Dennis Lawrence Cheung, Junichi Nabekura, Kanji Sugita, Masao Aihara, Schuichi Koizumi
This study shows that sequential activation of microglia and astrocytes contributes to epileptogenesis after status epilepticus, with reactive astrocytes playing a key role in seizure susceptibility.
JCI Insight · Apr 8, 2021Peer-reviewedNeuroscience