Katsuhiko Mikoshiba

Large-scale dimensional behavioral profiling dissociates fear memory from locomotor confounds in mice: The necessity of baseline-normalized metrics

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism.

The paper shows that an optimal ER-mitochondria distance of ~20 nm is critical for efficient Ca2+ transfer and mitochondrial oxidative metabolism, with reduced distances observed in Parkinson's disease astrocytes.

Ten-eleven translocation 1 Mediated-DNA Hydroxymethylation is Required for Myelination and Remyelination in the Mouse Brain

This study shows that Tet1-mediated DNA hydroxymethylation is essential for myelination and remyelination in mice by regulating oligodendrocyte differentiation and calcium signaling.

Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus

This study shows that sequential activation of microglia and astrocytes contributes to epileptogenesis after status epilepticus, with reactive astrocytes playing a key role in seizure susceptibility.