Asymmetric DNA targeting by RNA-guided TIGR-Tas systems
Kaoling Guran, Nathan M. Appleby, Boyu Huang, Dhruv Champaneri, Griffin P Shelly, K. M. Mazharul Alam, Piyush Jain, David Ward Taylor
This study investigates how TIGR-Tas systems recognize and cleave DNA targets, revealing asymmetric target engagement and coordinated cleavage across both RNA-DNA heteroduplexes.
bioRxiv · Oct 8, 2026 · PreprintBiochemistry