Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East Respiratory Syndrome coronavirus disease severity
Amy María Sims, Alexandra Schäfer, Kenichi Okuda, Sarah R. Leist, Jacob F. Kocher, Adam S. Cockrell, Padraig E. Hawkins, Minako Furusho, Kara L. Jensen, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Kelly G. Stratton, Natalie C. Lamar, Carrie D. Niccora, Karl K. Weitz, , Timothy Patrick Sheahan
This study uses multi-omics analysis to show that dysregulated lung epithelial cell homeostasis and immune responses drive severe MERS-CoV disease in mice.
mSphere · Jan 30, 2025Peer-reviewedMicrobiology