Jennifer E Kyle

Circadian immunometabolic states impart a temporal response to SARS-CoV-2 spike proteins in mammalian macrophages

This study investigates how circadian rhythms affect macrophage responses to SARS-CoV-2 spike proteins, finding that timing of exposure leads to distinct immunometabolic states.

CD248 activates TGF-β receptor I to promote vascular remodeling in pulmonary arterial hypertension

This study identifies CD248 as a co-activator of TGF-β receptor I in pulmonary arterial hypertension, supporting anti-CD248 therapy as a targeted alternative to systemic TGF-β inhibition.

Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection

Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East Respiratory Syndrome coronavirus disease severity

This study uses multi-omics analysis to show that dysregulated lung epithelial cell homeostasis and immune responses drive severe MERS-CoV disease in mice.

Changes in maternal blood and placental lipidomic profile in obesity and gestational diabetes: Evidence for sexual dimorphism

The paper examines lipidomic changes in maternal blood and placental tissue in obesity and gestational diabetes, revealing sexually dimorphic effects in placental fatty acid composition.

Systematic analysis of the sphingomyelin synthase family in C. elegans

The paper systematically analyzes the sphingomyelin synthase family in C. elegans, identifying three SM synthases and one CPE synthase with distinct subcellular distributions.

Novel insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis.

This study identifies Npt2b and pulmonary osteoclast-like cells as key regulators of phosphate homeostasis and microlith clearance in PAM.

The unknown lipids project: harmonized methods improve compound identification and data reproducibility in an inter-laboratory untargeted lipidomics study

The paper improves compound identification and inter-laboratory reproducibility in untargeted lipidomics using harmonized methods and spectral analysis.

From plants to ants: Fungal modification of leaf lipids for nutrition and communication in the leaf-cutter ant fungal garden ecosystem

This study uses lipidomics to analyze leaf-cutter ant fungal gardens, showing lipids play roles in energy transfer and inter-kingdom communication through differential fatty acid responses.

The role of islet lipid composition remodeling in regulation of beta-cell death via ADP-ribosyl-acceptor glycohydrolase ARH3 signaling in insulitis

The paper investigates lipid composition changes in insulitis models and identifies ARH3 as a regulator of beta-cell apoptosis through PLA2G6 signaling.

A generalizable method for false-discovery rate estimation in mass spectrometry-based lipidomics

This paper introduces a generalizable method for estimating false discovery rates in mass spectrometry-based lipidomics to enable automated data analysis.

Integrated systems biology and imaging of the smallest free-living eukaryote Ostreococcus tauri

The paper uses multimodal imaging and multi-omics techniques to study O. tauri's cellular responses to nitrogen and carbon ratio changes, revealing shifts in lipid and starch metabolism.