Timothy Patrick Sheahan

Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness and pathogenesis of SARS-CoV-2

This study shows that SARS-CoV-2 with impaired nsp14-exonuclease activity has reduced replication, fitness, and pathogenesis, but remains viable in some conditions.

An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma

This study develops an immunocompetent mouse model of virus-induced liver fibrosis and hepatocellular carcinoma using Norway rat hepacivirus.

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

This study isolates and characterizes neutralizing antibodies against HCoV-229E, showing one antibody induces conformational changes in the viral spike protein.

Structural Definition of Neutralizing Epitopes within and around the HKU1 Receptor-binding Site Reveals Cell Context-Dependent Neutralization

This study identifies mAbs targeting HCoV-HKU1 spike protein and shows that receptor-binding site recognition alone does not predict neutralization in primary cells.

Mouse Adapted Omicron BA.5 Induces A Fibrotic Lung Disease Phenotype in BALB/c Mice

This paper develops a mouse model of SARS-CoV-2 BA.5 infection that induces fibrotic lung disease and tertiary lymphoid structures, enabling study of acute and post-acute sequelae of COVID-19.

Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East Respiratory Syndrome coronavirus disease severity

This study uses multi-omics analysis to show that dysregulated lung epithelial cell homeostasis and immune responses drive severe MERS-CoV disease in mice.