Kristin Burnum-Johnson

ChatGEM: An Agentic Architecture Enabling Interactive Simulation of Genome-Scale Metabolic Models

ChatGEM enables interactive simulation of genome-scale metabolic models via natural language, improving performance and reducing execution time for complex tasks.

Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East Respiratory Syndrome coronavirus disease severity

This study uses multi-omics analysis to show that dysregulated lung epithelial cell homeostasis and immune responses drive severe MERS-CoV disease in mice.

Changes in maternal blood and placental lipidomic profile in obesity and gestational diabetes: Evidence for sexual dimorphism

The paper examines lipidomic changes in maternal blood and placental tissue in obesity and gestational diabetes, revealing sexually dimorphic effects in placental fatty acid composition.

Proteome mapping of the human pancreatic islet microenvironment reveals endocrine-exocrine signaling sphere of influence

The paper develops a spatial proteomics method to map the human pancreatic islet microenvironment and identifies spatial gradients in RNA processing proteins.

Uncovering hidden members and functions of the soil microbiome using de novo metaproteomics

This paper introduces a de novo metaproteomics pipeline using a deep learning model to identify soil microbiome composition and functions without relying on metagenomic data.

From plants to ants: Fungal modification of leaf lipids for nutrition and communication in the leaf-cutter ant fungal garden ecosystem

This study uses lipidomics to analyze leaf-cutter ant fungal gardens, showing lipids play roles in energy transfer and inter-kingdom communication through differential fatty acid responses.

The role of islet lipid composition remodeling in regulation of beta-cell death via ADP-ribosyl-acceptor glycohydrolase ARH3 signaling in insulitis

The paper investigates lipid composition changes in insulitis models and identifies ARH3 as a regulator of beta-cell apoptosis through PLA2G6 signaling.

Broad substrate-specific phosphorylation events are associated with the initial stage of plant cell wall recognition in Neurospora crassa

The paper investigates substrate-specific phosphorylation events in Neurospora crassa during early plant cell wall recognition using phospho-proteomics and identifies key signaling pathways and proteins involved.