Direct tensile force activates Adgrl3 in a tethered agonist-dependent manner
Jesper Holmkvist, Luis E. Hamel Ascanio, Younes Farhangi Barooji, Yin Kwan Chung, Rajesh Regmi, Phillip C. Vejre, Júlia Rosell-Teixidó, Karen L. Martinez, METTE MARIE ROSENKILDE, Poul Martin Bendix, Jonathan A. Javitch, Signe Mathiasen
The paper shows that direct tensile force on Adgrl3's N-terminus activates G protein recruitment in living cells, requiring a functional tethered agonist and force-driven conformational changes.
bioRxiv · Mar 1, 2026 · PreprintCell Biology