Signe Mathiasen

This paper introduces a method to measure spontaneous curvature in cellular membranes using tether pulling and simulations, revealing baseline negative curvature and its modulation by treatments.

This paper introduces a quantitative imaging framework to study GPCR oligomerization in living cells, revealing density-dependent monomer-dimer equilibria and apparent affinities for dimerization.

The paper shows that direct tensile force on Adgrl3's N-terminus activates G protein recruitment in living cells, requiring a functional tethered agonist and force-driven conformational changes.

This study shows that increasing μ-opioid receptor density promotes trafficking via GRK2/3 and β-arrestin interactions, while class B GPCRs block trafficking by sequestering β-arrestin.