Author

Jesper Holmkvist

University of CopenhagenORCID 0000-0002-0762-4313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Aleksander CvjetkoviciD· 1 shared Alessandra NarducciiD· 1 shared Bo Højen Justesen· 1 shared Christopher G. ShuttleiD· 1 shared Dimitrios G. StamouiD· 1 shared Eleftherios KosmidisiD· 1 shared Ida Louise Jørgensen· 1 shared Jonathan A. JavitchiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

Aleksander CvjetkovicORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Direct tensile force activates Adgrl3 in a tethered agonist-dependent manner

Jesper Holmkvist, Luis E. Hamel Ascanio, Younes Farhangi Barooji, Yin Kwan Chung, Rajesh Regmi, Phillip C. Vejre, Júlia Rosell-Teixidó, Karen L. Martinez, METTE MARIE ROSENKILDE, Poul Martin Bendix, Jonathan A. Javitch, Signe Mathiasen

The paper shows that direct tensile force on Adgrl3's N-terminus activates G protein recruitment in living cells, requiring a functional tethered agonist and force-driven conformational changes.

bioRxiv · Mar 1, 2026 · PreprintCell Biology

Long-term single-molecule Ca2+ flux recordings reveal mode-switching regulation of Ca2+-ATPases

Mads P. Møller, Aleksander Cvjetkovic, Eleftherios Kosmidis, Alessandra Narducci, Michael Isselstein, Christopher G. Shuttle, Bo Højen Justesen, Ida Louise Jørgensen, Sara Basse Hansen, Mateusz Dyla, Jesper Holmkvist, Magnus Kjærgaard, Per Amstrup Pedersen, Poul Nissen, Thomas Günther Pomorski, Dimitrios G. Stamou

This study uses single-molecule recordings to show Ca2+-ATPases switch between active and inactive modes, revealing a new regulatory mechanism for Ca2+ homeostasis.

bioRxiv · Jan 31, 2026 · PreprintBiophysics