Author

Karen Lettieri

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Samuel L. PfaffiD· 3 shared Claire E. Williams· 2 shared Kip J. Hermann· 2 shared Lukas C. Bachmann· 2 shared Miriam GulloiD· 2 shared Ryan H. HsuiD· 2 shared Stella Kramer· 2 shared Brendan O’Leary· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMolecular Biology

Samuel L. PfaffORCID

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Author profile →

3 papers

Recent·Most cited

RNA trans-splicing treatment for Duchenne muscular dystrophy

Ryan H. Hsu, Claire E. Williams, Geraldine Maier, Miriam Gullo, Karen Lettieri, Cindy J. Alvarez, Kip J. Hermann, Stella Kramer, Satchidananda Panda, Lukas C. Bachmann, Samuel L. Pfaff

The paper develops a multi-vector RNA End Joining system for Duchenne muscular dystrophy that enables efficient expression of large therapeutic proteins with minimal off-target effects.

bioRxiv · Sep 16, 2026 · PreprintMolecular Biology

An intersectional expression platform for gene complementation using RNA-fragment end joining (REJ)

Lukas C. Bachmann, Ryan H. Hsu, Kip J. Hermann, Claire E. Williams, Richard L. Farman, Nicolas Criales, Craig Clark, Stella Kramer, Carolina Thörn Pérez, Sawyer Randles, Karen Lettieri, Samuel L. Pfaff

This paper introduces an RNA-fragment end joining (REJ) platform for gene complementation that enables precise and efficient splicing of RNA units into functional mRNAs.

bioRxiv · Sep 14, 2026 · PreprintMolecular Biology

Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

Lydia Daboussi, Giancarlo Costaguta, Miriam Gullo, Nicole Jasinski, Veronica Pessino, Brendan O’Leary, Karen Lettieri, Shawn P. Driscoll, Samuel L. Pfaff

This study identifies Mitf as a key regulator of Schwann cell plasticity in nerve repair, showing its role in axonal integrity sensing and recovery from peripheral neuropathies.

Cell Reports · Oct 28, 2023Peer-reviewedNeuroscience