Veronica Pessino

This study identifies Mitf as a key regulator of Schwann cell plasticity in nerve repair, showing its role in axonal integrity sensing and recovery from peripheral neuropathies.

Long single-stranded DNA donors enable gene-sized CRISPR knock-in in human cells, though an author update notes subsequent long-read sequencing revealed high imprecise integration rates for both donor types.

Long-read sequencing with the knock-knock pipeline profiles CRISPR knock-in repair, finding perfect homology-directed repair is often a minority of integration events and mis-integration varies by context.