Samuel L. Pfaff

RNA trans-splicing treatment for Duchenne muscular dystrophy

The paper develops a multi-vector RNA End Joining system for Duchenne muscular dystrophy that enables efficient expression of large therapeutic proteins with minimal off-target effects.

An intersectional expression platform for gene complementation using RNA-fragment end joining (REJ)

This paper introduces an RNA-fragment end joining (REJ) platform for gene complementation that enables precise and efficient splicing of RNA units into functional mRNAs.

A genetically-defined population of amygdalofugal neurons promotes suckling and early postnatal growth

The paper identifies a specific neuronal population in the central amygdala that promotes suckling and early postnatal growth in mice.

Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

This study identifies Mitf as a key regulator of Schwann cell plasticity in nerve repair, showing its role in axonal integrity sensing and recovery from peripheral neuropathies.

A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements

The paper identifies a spinal microcircuit involving V2a and V2b neurons that coordinate ipsilateral body movements during locomotion, showing antagonistic and synergistic roles in motor control.

Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled

The paper investigates the spatial organization of spinal premotor interneurons controlling flexor and extensor muscles, finding they are intermingled rather than segregated.