Patient-specific therapeutic benefit of MuSK agonist antibody ARGX-119 in MuSK myasthenia gravis passive transfer models
Jamie L. Lim, Stine Marie Jensen, Jaap J. Plomp, Bernhardt Vankerckhoven, Christa Kneip, Rani Coppejans, Christophe Steyaert, Kathleen Moens, Lieselot De Clercq, Martijn Rudolf Tannemaat, Peter Ulrichts, Karen Silence, Silvère M. van der Maarel, Dana L.E. Vergoossen, Roeland Vanhauwaert, , Maartje G. M. Huijbers
This study shows that the MuSK agonist antibody ARGX-119 can rescue MuSK myasthenia gravis in a patient-specific manner, with efficacy linked to the presence of MuSK activating antibodies in some patients.
iScience · Dec 21, 2024Peer-reviewedNeuroscience