Shohei Koide

The paper shows WDR5 binds RNA non-specifically, displacing it from the MLL1 complex and inhibiting its catalytic activity.

This paper reports the cryo-EM structure of a TrkA-neutralizing antibody complex, revealing its mechanism of isoform selectivity and therapeutic potential for chronic pain.

This study develops antibody-drug conjugates targeting CD97, an aGPCR overexpressed in cancer, showing efficacy against AML and GBM cells with minimal off-target toxicity.

This paper develops a monobody-drug conjugate targeting mutant RAS in multiple myeloma, showing improved anti-tumor effects and safety in vitro and in vivo.

ARGX-119 is a novel first-in-class MuSK agonist monoclonal antibody in clinical development for treatment of neuromuscular diseases.

This study re-evaluates the bivalency model using a new ChIP method, finding widespread bivalency that does not resolve with differentiation and is not specific for poised developmental genes.