Maartje G. M. Huijbers

The paper examines IgG4 antibody repertoire stability over time in health and autoimmune diseases, finding that most clones remain stable despite treatment.

This study investigates how valency and epitope specificity of MuSK antibodies affect MuSK signaling, revealing distinct impacts on binding kinetics, Dok7 binding, and gene expression.

This study identifies distinct transcriptional programs in human IgG4+ memory B cells, revealing unique features and potential therapeutic targets.

The paper introduces an LC-MS method to analyze IgG4 repertoires with clonal resolution, revealing high diversity and persistence of IgG4 molecules in serum over time.

This study shows that the MuSK agonist antibody ARGX-119 can rescue MuSK myasthenia gravis in a patient-specific manner, with efficacy linked to the presence of MuSK activating antibodies in some patients.

ARGX-119 is a novel first-in-class MuSK agonist monoclonal antibody in clinical development for treatment of neuromuscular diseases.

The paper investigates the spatio-temporal expression of MG-related genes in human tissues and the CNS using public datasets, identifying new tissues and brain regions with high expression.