Reduced late endosome/lysosome function promotes SLE through chronic PI3k activity and SHP-1/SHIP-1 defects
SunAh Kang, Andrew J. Monteith, Liubov S Arbeeva, Karissa Grier, Shruti Saxena Beem, Anthony Trujillo, Xinyun Bi, Kai Sun, Rebecca E. Sadun, Mithu Maheswaranathan, Megan E. B. Clowse, Saira Zafar Sheikh, Jennifer L Rogers, Barbara J. Vilen
This study identifies reduced late endosome/lysosome function in SLE patients, linked to chronic PI3k activity and SHP-1/SHIP-1 defects, and suggests it as a potential biomarker.
JCI Insight · Feb 10, 2026Peer-reviewedImmunology