Somatic genetic variation shapes clonal selection of memory NK cells
Timo Rückert, Matthias Günther, Oliver Knight, M Mandry, Karl Junker, Simon A. Grassmann, Joseph Chai-Yuen Sun, Thomas Höfer, Chiara Romagnani
Whole-exome sequencing of memory NK cells from 81 CMV-seropositive donors reveals dominant somatic clones, early-life origin, and positive selection, with Kmt2d loss shifting mouse NK fitness.
bioRxiv · Sep 18, 2026 · PreprintImmunology✦ In-depth digest