Thomas Höfer

Whole-exome sequencing of memory NK cells from 81 CMV-seropositive donors reveals dominant somatic clones, early-life origin, and positive selection, with Kmt2d loss shifting mouse NK fitness.

LACHESIS infers evolutionary trajectories of malignant transformation from whole-genome sequencing data and provides risk stratification for childhood and adult cancers.

This study identifies a mechanism of asynchronous nuclear division in Plasmodium falciparum that enhances proliferation by minimizing resource idling through sequential allocation of a limiting replication resource.

This study uses a cross-species bone marrow niche model to show that plasticity in the murine niche supports human HSC engraftment, highlighting its role in stem cell function.

This study uses single-cell transplantation and mathematical modeling to show that lineage biases in hematopoiesis arise from extrinsic feedback and clonal competition, not intrinsic HSC properties.

This study shows that myeloid differentiation in hematopoietic progenitors starts during S phase and is linked to chromatin changes and HOXA9 activity.

The paper tracks Flt3+ hematopoietic progenitors in vivo to show their lineage-restricted fates and long-lived output in immune cell compartments.

The paper traces individual PGC clones in mice to show early stochastic bottlenecks shape clonal contributions and reproductive success.

This study identifies recurrent DNA break clusters (RDCs) as causal factors for CNV formation under replication stress and shows DNA polymerase theta's role in preventing these events.

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

The paper investigates NSPC proliferation dynamics in a mouse model, finding that adaptive clonal expansion by a small fraction of NSPCs can regenerate the entire neuronal population.

The paper uses holistic genetic barcoding to map the lineage tree of tissue macrophage development in mice from gastrulation to adulthood, revealing local macrophage colonies that persist into adult organs.

The paper develops a kinetic model to explain variation in HLA-DM susceptibility of MHC-II peptides and identifies two mechanisms shaping antigen presentation.

The paper develops a computational framework to infer enhancer-gene networks in T helper cells, revealing T-bet expression intensity as critical for Th cell fate.

The paper develops a data-driven model of the circadian clock in Neurospora crassa using luciferase reporter data to estimate parameters and reveal the role of FRQ maturation in circadian rhythms.

The paper uses fate-mapping, single-cell RNA-sequencing, and computational methods to show that major hematopoietic lineages diverge within HSCs, identifying a self-renewing HSC subpopulation and a direct thrombopoiesis pathway.

This study shows interferon regulates stem cell function across all ages by controlling mTOR and cell cycle, with beneficial effects in youth and harmful effects in aging brains.

The paper investigates HSC division patterns in mice, finding most divisions are symmetric self-renewing, maintaining HSC output despite age-related decline in differentiation.

The paper shows that cell cycle length correlations in lineage trees reveal growth's role in controlling proliferation, identifying cell size and division license as key factors.

Synlet is an R package that provides a complete pipeline for analyzing synthetic lethal RNAi screen data, including quality assessment, normalization, and hit selection methods.