Author

Karl M. Kowalewski

University of Virginia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Matthew J. LazzaraiD· 2 shared Amanda PoissonnieriD· 1 shared Anne TalkingtoniD· 1 shared Ben Z. StangeriD· 1 shared Britney Chu· 1 shared Cody L. WolfiD· 1 shared Edward B. StelowiD· 1 shared Jason J. Wieder· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Matthew J. LazzaraORCID

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2 papers

Recent·Most cited

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer

Cody L. Wolf, Roxanne K. Ruiz, Sokchea Khou, Robert Cornelison, Edward B. Stelow, Karl M. Kowalewski, Matthew J. Lazzara, Amanda Poissonnier, Lisa M. Coussens, Kimberly A. Kelly

This study identifies plectin as a biomarker of aggressive pancreatic cancer, showing it suppresses T cell activity and that targeting it with an antibody enhances anti-tumor immunity.

Frontiers in Immunology · Aug 17, 2026Peer-reviewedCancer Biology

Hypoxia-induced histone methylation and NF-κB activation in pancreas cancer fibroblasts promote EMT-supportive growth factor secretion

Karl M. Kowalewski, Sara J. Adair, Anne Talkington, Jason J. Wieder, Jason Robert Pitarresi, Kia Z. Perez-Vale, Britney Chu, Sepideh Dolatshahi, Rosalie C. Sears, Ben Z. Stanger, Todd W. Bauer, Matthew J. Lazzara

The paper shows hypoxic fibroblasts in pancreas cancer use histone methylation and ROS-mediated NF-κB activation to produce growth factors that drive epithelial-mesenchymal transition in malignant cells.

bioRxiv · Jan 30, 2025 · PreprintCancer Biology