Cancer BiologybioRxivPreprint
Hypoxia-induced histone methylation and NF-κB activation in pancreas cancer fibroblasts promote EMT-supportive growth factor secretion
Karl M. Kowalewski, Sara J. Adair, Anne Talkington…·Matthew J. Lazzara
The paper shows hypoxic fibroblasts in pancreas cancer use histone methylation and ROS-mediated NF-κB activation to produce growth factors that drive epithelial-mesenchymal transition in malignant cells.