Hypoxia-induced histone methylation and NF-κB activation in pancreas cancer fibroblasts promote EMT-supportive growth factor secretion
Karl M. Kowalewski, Sara J. Adair, Anne Talkington, Jason J. Wieder, Jason Robert Pitarresi, Kia Z. Perez-Vale, Britney Chu, Sepideh Dolatshahi, Rosalie C. Sears, Ben Z. Stanger, Todd W. Bauer, Matthew J. Lazzara
The paper shows hypoxic fibroblasts in pancreas cancer use histone methylation and ROS-mediated NF-κB activation to produce growth factors that drive epithelial-mesenchymal transition in malignant cells.
bioRxiv · Jan 30, 2025 · PreprintCancer Biology