Eliminating the type I restriction endonuclease from Pseudomonas aeruginosa PAO1 for optimised phage isolation
Ellie J. Tong, Kate A. Bickerton, Alina J. Creber, Steven L. Porter, Ben Temperton
This paper removes the type I restriction endonuclease HsdR from Pseudomonas aeruginosa PAO1 to improve phage propagation efficiency and yield, enhancing phage isolation for clinical therapy.
bioRxiv · May 30, 2025 · PreprintMicrobiology