Ellie J. Tong

This study isolates a novel phage targeting the LPS inner core of Pseudomonas aeruginosa and shows that LPS modifications create a trade-off in resistance to two phages, suggesting that combining phages targeting different LPS regions can delay resistance.

This paper removes the type I restriction endonuclease HsdR from Pseudomonas aeruginosa PAO1 to improve phage propagation efficiency and yield, enhancing phage isolation for clinical therapy.