Ben Temperton

Biocontainment of phages inhibits bacterial clearance in micro niches

This study shows that biocontained phages are less effective at clearing bacteria in structured environments compared to wild-type phages.

Arbitrium phages can manipulate each other's lysis - lysogeny decisions

The paper shows that Arbitrium phages from different species can influence each other's lysis-lysogeny decisions through peptide-based communication, leading to fitness advantages and coevolution.

Lipopolysaccharide truncation and restoration drives a trade-off in resistance to two phages in Pseudomonas aeruginosa

This study isolates a novel phage targeting the LPS inner core of Pseudomonas aeruginosa and shows that LPS modifications create a trade-off in resistance to two phages, suggesting that combining phages targeting different LPS regions can delay resistance.

Seasonal patterns of exometabolites depend on microbial functions in the oligotrophic ocean

The paper examines seasonal exometabolite patterns in the oligotrophic ocean, linking microbial functions to DOM dynamics and showing DOM composition is more stable than microbial community structure.

Eliminating the type I restriction endonuclease from Pseudomonas aeruginosa PAO1 for optimised phage isolation

This paper removes the type I restriction endonuclease HsdR from Pseudomonas aeruginosa PAO1 to improve phage propagation efficiency and yield, enhancing phage isolation for clinical therapy.

Viral chronotypes and their role in shaping seasonal viral dynamics in the Western English Channel

The paper identifies viral chronotypes from time-series metagenomic data, revealing seasonal patterns and environmental influences on viral dynamics.

In field use of water samples for genomic surveillance of ISKNV infecting tilapia fish in Lake Volta, Ghana

The paper demonstrates the use of water samples for real-time genomic surveillance of ISKNV in Lake Volta, Ghana, showing that water samples can detect viral variants matching those from infected fish.

MetaPop: A pipeline for macro- and micro-diversity analyses and visualization of microbial and viral metagenome-derived populations

MetaPop analyzes and visualizes microbial and viral metagenome-derived populations at macro- and micro-diversity levels, revealing lower viral nucleotide diversity in autistic children.

Long-read viral metagenomics enables capture of abundant and microdiverse viral populations and their niche-defining genomic islands

The paper introduces VirION, a long-read sequencing method for viral metagenomics that improves genome assembly and captures microdiverse viral populations and genomic islands.