Aging alters tumor cell - T cell crosstalk to promote breast cancer progression
Shanshan Yin, Kay T. Yeung, Sainath Mamde, Kate Lin, Armin Gandhi, Xue Lei, Andrew Davis, Rouven Arnold, Jing Yang, Peter D. Adams
This study shows that aging reduces T cell recruitment in breast cancer by decreasing Cxcl9/Cxcl10 expression in tumor cells, leading to weakened anti-tumor immunity.
bioRxiv · Nov 17, 2025 · PreprintCancer Biology