Author

Shanshan Yin

Sanford Burnham Prebys Medical Discovery InstituteORCID 0000-0001-6907-9384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Andrew Davis· 3 shared Armin GandhiiD· 3 shared Peter D. AdamsiD· 3 shared Rouven Arnold· 3 shared Xue LeiiD· 3 shared Aaron P. HavasiD· 2 shared Adarsh RajeshiD· 2 shared Angela LiouiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Andrew Davis

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3 papers

Recent·Most cited

Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling and associates with impaired neighboring T cell function.

Armin Gandhi, Kathryn Lande, Kelly Yichen Li, Filipe Araujo Hoffmann, Michael LaPorte, Shirong Tan, K. Garrett Evensen, Benji Portillo, Marcos G. Teneche, Rouven Arnold, Adarsh Rajesh, Jessica Proulx, Shanshan Yin, Aaron P. Havas, Angela Liou, , Peter D. Adams

This study shows that aging-induced CD44 in hepatocytes activates the IL6/JAK/STAT3 pathway, leading to impaired T cell function in the liver.

npj Aging · Aug 13, 2026Peer-reviewedCell Biology

HIRA-mediated H3.3 deposition preserves hepatocyte cell identity during liver aging

Rouven Arnold, Marcos G. Teneche, Xue Lei, Armin Gandhi, Christina Huan Shi, Jessica M. Proulx, Adarsh Rajesh, Aaron P. Havas, Shiqi Su, Annanya Sethiya, Shanshan Yin, Hiroshi Tanaka, Zong Ming Chua, Andrew Davis, Laurence Haddadin, , Peter D. Adams

This study shows that HIRA-mediated H3.3 deposition maintains hepatocyte identity during aging, and its loss leads to metabolic dysfunction and fibrosis, which can be partially reversed by tissue regeneration.

bioRxiv · Mar 11, 2026 · PreprintGenomics

Aging alters tumor cell - T cell crosstalk to promote breast cancer progression

Shanshan Yin, Kay T. Yeung, Sainath Mamde, Kate Lin, Armin Gandhi, Xue Lei, Andrew Davis, Rouven Arnold, Jing Yang, Peter D. Adams

This study shows that aging reduces T cell recruitment in breast cancer by decreasing Cxcl9/Cxcl10 expression in tumor cells, leading to weakened anti-tumor immunity.

bioRxiv · Nov 17, 2025 · PreprintCancer Biology