Jane Yang

This paper identifies a host-encoded toggle switch involving NOD2 and GIV that controls cAMP levels in macrophages, converting tolerant cells into microbicidal machines to restore microbial clearance and gut barrier integrity.

The paper shows common and rare genetic variants converge on shared molecular networks for most human traits, influenced by heritability and tissue specificity.

This study shows that TYK2 suppresses breast cancer metastasis under low ECM stiffness by promoting EMT, and its localization changes with ECM rigidity.

This study shows that aging reduces T cell recruitment in breast cancer by decreasing Cxcl9/Cxcl10 expression in tumor cells, leading to weakened anti-tumor immunity.

The paper shows that desmosome mutations in keratinocytes of the tumor microenvironment promote melanoma proliferation through reduced desmosome gene expression and increased melanoma cell growth.

This study identifies 14 genome-wide significant loci for delay discounting in 134,935 individuals and shows genetic associations with 212 medical conditions.