Cross-regulation of (p)ppGpp and c-di-GMP pathways controls a cell-cycle transition
Corentin Jaboulay, Chloé Dugelay, José P.S. Maio, Katell Beillevaire, Philippe Vogeleer, Daniel Vinella, Fabien Létisse, Régis Hallez, Boyuan Wang, Laurent Terradot, Mathilde Guzzo
The paper shows (p)ppGpp inhibits c-di-GMP synthesis in Caulobacter crescentus, linking metabolic stress to developmental arrest through direct molecular interaction.
bioRxiv · Aug 22, 2025 · PreprintMicrobiology