Fabien Létisse

This study identifies mutations in spoT that reduce (p)ppGpp levels, enhancing Ralstonia pseudosolanacearum adaptation to plant xylem and legume nodules without compromising virulence.

This paper describes the metabolic engineering of E. coli to produce β-mannobiose and laminaribiose from mannose, achieving high product titers and yields through pathway optimization.

This study shows that inhibiting glycolysis in TB-infected macrophages reduces HIV-1 spread by blocking tunneling nanotubes and Siglec-1 expression.

The paper shows (p)ppGpp inhibits c-di-GMP synthesis in Caulobacter crescentus, linking metabolic stress to developmental arrest through direct molecular interaction.

IsoSolve integrates isotopic measurements from MS and NMR to improve isotopic coverage and consolidate data for metabolic network analysis.

This study develops a kinetic model of E. coli metabolism to explain acetate overflow, showing acetate regulates glucose metabolism and is not a wasteful by-product.

This study investigates the role of (p)ppGpp in E. coli's recovery from growth disruption caused by serine hydroxamate, showing ppGpp is crucial for growth recovery while pppGpp has no significant effect.

This study enhances odd-chain fatty acid production in Yarrowia lipolytica by engineering precursor pools and optimizing culture conditions, achieving 1.87 g/L OCFA titer.