Intravital Cholesterol Depletion Reduces Membrane Dynamics and Increases Mechanosensitivity in Osteocytes In Vivo
Melia D. Matthews, Katelyn Lunny, Lakhi Raju, Nada Naguib, Sainya Tariq, Ulrich B. Wiesner, Karl J. Lewis
This study shows that cholesterol depletion in osteocytes reduces membrane dynamics and alters mechanosensitivity, with sex-dependent effects on Ca2+ signaling in response to mechanical loading.
bioRxiv · Jul 31, 2026 · PreprintCell Biology