Immunotherapy with nebulized pattern recognition receptor agonists restores severe immune paralysis and improves outcomes in mice with influenza-associated pulmonary aspergillosis
Jezreel Pantaleón García, Sebastian Wurster, Nathaniel D. Albert, Uddalak Bharadwaj, Keerthi Bhoda, Vikram K Kulkarni, Mbaya Ntita, Paris Rodríguez Carstens, Madeleine Burch-Eapen, Daniela Covarrubias López, Jania Foncerrada Lizaola, Katherine E. Larsen, Lauren M. Matula, Seyed Javad Moghaddam, Yongxing Wang, , Scott E. Evans
This study shows that nebulized Toll-like receptor agonists improve survival and immune function in a mouse model of influenza-associated pulmonary aspergillosis.
mBio · Apr 8, 2025Peer-reviewedImmunology