Author

Seyed Javad Moghaddam

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-5350-307XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Jezreel Pantaleón GarcíaiD· 2 shared Scott E. EvansiD· 2 shared Yongxing WangiD· 2 shared Ansam F. SinjabiD· 1 shared Avrum E. SpiraiD· 1 shared Beatriz Sánchez‐EspiridióniD· 1 shared Boning GaoiD· 1 shared Boris SepesiiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

Jezreel Pantaleón GarcíaORCID

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3 papers

Recent·Most cited

Immunotherapy with nebulized pattern recognition receptor agonists restores severe immune paralysis and improves outcomes in mice with influenza-associated pulmonary aspergillosis

Jezreel Pantaleón García, Sebastian Wurster, Nathaniel D. Albert, Uddalak Bharadwaj, Keerthi Bhoda, Vikram K Kulkarni, Mbaya Ntita, Paris Rodríguez Carstens, Madeleine Burch-Eapen, Daniela Covarrubias López, Jania Foncerrada Lizaola, Katherine E. Larsen, Lauren M. Matula, Seyed Javad Moghaddam, Yongxing Wang, , Scott E. Evans

This study shows that nebulized Toll-like receptor agonists improve survival and immune function in a mouse model of influenza-associated pulmonary aspergillosis.

mBio · Apr 8, 2025Peer-reviewedImmunology

Omics-Based Interaction Framework - a systems model to reveal molecular drivers of synergy

Jezreel Pantaleón García, Vikram V. Kulkarni, Tanner C. Reese, Shradha Wali, Saima J. Wase, Jiexin Zhang, Ratnakar Singh, Mauricio S. Caetano, Seyed Javad Moghaddam, Faye M. Johnson, Jing Wang, Yongxing Wang, Scott E. Evans

The paper introduces OBIF, a systems model that identifies molecular drivers of synergy by integrating statistical and biological interactions from omics data.

bioRxiv · Apr 16, 2020 · PreprintSystems Biology

Single-cell analysis of human lung epithelia reveals concomitant expression of the SARS-CoV-2 receptor ACE2 with multiple virus receptors and scavengers in alveolar type II cells

Guangchun Han, Ansam F. Sinjab, Warapen Treekitkarnmongkol, Patrick M. Brennan, Kieko Hara, Kyle Chang, Elena Bogatenkova, Beatriz Sánchez‐Espiridión, Carmen Behrens, Boning Gao, Luc Girard, Jianjun Zhang, Boris Sepesi, Tina Cascone, Lauren A. Byers, , Humam N. Kadara

The paper analyzes single-cell RNA-seq data to identify ACE2 expression patterns in human lung epithelial cells, finding high ACE2 expression in alveolar type II cells and co-expression with pathogen receptors.

bioRxiv · Apr 16, 2020 · PreprintGenomics