Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a Drosophila cachexia model
Callum Dark, Nashia Ali, Sofia Golenkina, Ronnie Blazev, Benjamin L. Parker, Katherine Murphy, Gordon Stuart Lynch, Tarosi Senapati, S. Sean Millard, Sarah M. Judge, Andrew R. Judge, Louise Y Cheng
This study identifies mitochondrial fusion and beta-oxidation as key drivers of muscle wasting in a Drosophila cancer cachexia model and shows interventions can mitigate muscle loss.
bioRxiv · Jun 23, 2023 · PreprintDevelopmental Biology