Cocaine-dependent acquisition of locomotor sensitization and conditioned place preference requires D1 dopaminergic signaling through a cyclic AMP, NCS-Rapgef2, ERK and Egr-1/Zif268 pathway
Sunny Zhihong Jiang, Sean C. Sweat, Sam P. Dahlke, Kathleen Loane, Gunner Drossel, Wenqin Xu, Hugo A. Tejeda, Charles R. Gerfen, Lee E. Eiden
This study identifies a novel cAMP-NCS-Rapgef2-ERK-Egr-1/Zif268 pathway in D1 dopamine receptor neurons of the nucleus accumbens that is essential for cocaine-induced locomotor sensitization and conditioned place preference.
Journal of Neuroscience · Dec 2, 2020Peer-reviewedNeuroscience