Charles R. Gerfen

The paper shows that visual stimuli evoke dopamine in the dorsomedial striatum via cholinergic-dependent mechanisms, driven by frontal cortices rather than sensory cortices.

This paper introduces a new optical framework and imaging devices that enable scalable, high-resolution, multi-immersion light-sheet microscopy for biological samples.

This study investigates the role of cAMP-dependent signaling pathways in cocaine-induced immediate-early gene expression in D1 medium-spiny neurons of the nucleus accumbens, identifying distinct pathways for Egr-1 and c-Fos induction.

The paper introduces ATLAS, an anterograde transsynaptic tracer based on an antibody-like protein, which enables non-toxic, synaptic, and activity-dependent circuit tracing in vivo and in dissociated cultures.

The paper investigates how levodopa-induced dyskinesia is linked to increased activity in specific striatal direct pathway medium spiny neurons, driven by dopamine and excitatory inputs.

The paper investigates the roles of the frontal cortex and striatum in motor timing by using perturbation experiments in mice, showing that the striatum integrates cortical input to regulate timing.

The paper compares topographic precision of ipsilateral and contralateral cortical projections in frontal, motor, and somatosensory areas of mice, finding stronger contralateral projections in frontal regions.

This study shows that cell-type-specific synaptic plasticity in PT neurons is essential for shaping neocortical dynamics during motor learning.

The paper identifies distinct brain-wide presynaptic networks that underlie the functional identity of individual cortical neurons based on their behavioral state-dependent activity.

This study shows that specific cell types in the superior colliculus modulate choice activity in frontal cortex through bidirectional interactions during decision-making.

The paper examines how cortical and thalamic inputs target specific inhibitory neurons in mouse motor cortex, revealing distinct laminar and cell-type-specific connectivity patterns.

The paper shows how midbrain and thalamic circuits reorganize motor cortex dynamics to transition from planning to execution of movement.

The paper identifies distinct prefrontal circuits targeting anterior and posterior dorsal striatum subregions and characterizes their roles in action control during a choice task.

The paper investigates the role of PACAP signaling in neuronal subpopulations by analyzing its distribution and effects on behavior and gene expression in mice.

This study identifies a novel cAMP-NCS-Rapgef2-ERK-Egr-1/Zif268 pathway in D1 dopamine receptor neurons of the nucleus accumbens that is essential for cocaine-induced locomotor sensitization and conditioned place preference.

The paper identifies an amygdala circuit that mediates experience-dependent momentary exploratory arrests in mice without affecting place preference or anxiety-like behaviors.

The paper identifies Npas1+-Nkx2.1+ neurons as a distinct subclass of GPe neurons and describes their role in the cortico-pallido-cortical loop.

The paper expands the Allen Mouse Brain Connectivity Atlas by analyzing intracortical connections at the layer and cell class level, revealing modular organization and distinct projection patterns.

NeuroInfo automatically registers experimental mouse brain sections with a 3D atlas to accurately identify brain regions, improving navigation and reducing observer error.

The paper reconstructs 1,000 projection neurons in the mouse brain, revealing new cell types and organizational principles of long-range connectivity.

The paper identifies two types of motor cortex neurons with distinct roles in movement preparation and execution using single-cell profiling and axonal reconstructions.

This study compares somatotopic precision in corticostriatal projections from two cortical cell types, finding IT-type neurons show higher stereotypy than PT-type neurons.