Author

Sean C. Sweat

National Institutes of HealthORCID 0000-0002-7598-3166Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

Gunner DrosseliD· 2 shared Lee E. EideniD· 2 shared Sunny Zhihong JiangiD· 2 shared Wenqin XuiD· 2 shared Ashley M. KopeciD· 1 shared Babru Bahan Samal· 1 shared Caroline J. W. SmithiD· 1 shared Charles R. GerfeniD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Gunner DrosselORCID

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Author profile →

4 papers

Recent·Most cited

Longitudinal Assessment of Fluorescence Stability Shows Fluorescence Intensity Decreases Over Time: Implications for Fluorescence Microscopy Studies

Sean C. Sweat, Sarah P.R. Berg, Tenzin Kunkhyen, Emma G. Foster, Claire E. J. Cheetham

This study shows fluorescence intensity decreases over six weeks in IHC, influenced by antibody choices and staining methods, highlighting the need for imaging best practices.

PLoS ONE · Mar 5, 2026Peer-reviewedNeuroscience

Relationship between constitutive and acute gene regulation, and physiological and behavioral responses, mediated by the neuropeptide PACAP

Dana Bakalar, Sean C. Sweat, Gunner Drossel, Sunny Zhihong Jiang, Babru Bahan Samal, Nikolas Stroth, Wenqin Xu, Limei Zhang, Hai‐Ying Zhang, Lee E. Eiden

The paper identifies constitutive and acute transcriptomic effects of PACAP deficiency in mice, revealing distinct mechanisms of neuropeptide action on physiological and behavioral responses.

Psychoneuroendocrinology · Oct 18, 2021Peer-reviewedNeuroscience

Cocaine-dependent acquisition of locomotor sensitization and conditioned place preference requires D1 dopaminergic signaling through a cyclic AMP, NCS-Rapgef2, ERK and Egr-1/Zif268 pathway

Sunny Zhihong Jiang, Sean C. Sweat, Sam P. Dahlke, Kathleen Loane, Gunner Drossel, Wenqin Xu, Hugo A. Tejeda, Charles R. Gerfen, Lee E. Eiden

This study identifies a novel cAMP-NCS-Rapgef2-ERK-Egr-1/Zif268 pathway in D1 dopamine receptor neurons of the nucleus accumbens that is essential for cocaine-induced locomotor sensitization and conditioned place preference.

Journal of Neuroscience · Dec 2, 2020Peer-reviewedNeuroscience

Microglial elimination of dopamine D1 receptors defines sex-specific changes in nucleus accumbens development and social play behavior during adolescence

Ashley M. Kopec, Caroline J. W. Smith, Nathan R. Ayre, Sean C. Sweat, Staci D. Bilbo

This study shows microglia eliminate dopamine D1 receptors in the nucleus accumbens, influencing sex-specific social play behavior during adolescence.

bioRxiv · Oct 29, 2017 · PreprintNeuroscience