Guiding treatment response by spatiotemporal control of α-particle deposition in solid tumors: the case for 'affinity cocktails' of antibody-radioconjugates
Rajiv Ranjit Nair, Aira Sarkar, Pooja Hariharan, Michail E. Kavousanakis, Rohit Chaudhari, Remco Bastiaannet, Kathlyn Gabrielson, Stavroula Sofou
This paper demonstrates that using affinity cocktails of antibody-radioconjugates improves tumor irradiation by combining high- and low-affinity variants to target different tumor regions, leading to better treatment outcomes.
bioRxiv · Dec 25, 2025 · PreprintBioengineering