Michail E. Kavousanakis

This paper demonstrates that using affinity cocktails of antibody-radioconjugates improves tumor irradiation by combining high- and low-affinity variants to target different tumor regions, leading to better treatment outcomes.

This paper develops a digital twin model to optimize targeted alpha-particle therapies using antibody-radioconjugate cocktails, showing improved tumor spheroid growth inhibition with mixed affinity conjugates.

This study models tumor growth and macrophage dynamics in a multiphase system, showing how macrophage heterogeneity affects tumor progression and proposing an immunotherapeutic strategy.

This study uses a continuum-level model to show that combining radiation with anti-VEGF and chemotherapy improves tumor suppression in growing vascular tumors.

The paper addresses delivery heterogeneity in tumors by developing carrier cocktails that achieve spatial delivery uniformity through complementary delivery properties.