Stavroula Sofou

This paper demonstrates that using affinity cocktails of antibody-radioconjugates improves tumor irradiation by combining high- and low-affinity variants to target different tumor regions, leading to better treatment outcomes.

This paper develops a digital twin model to optimize targeted alpha-particle therapies using antibody-radioconjugate cocktails, showing improved tumor spheroid growth inhibition with mixed affinity conjugates.

This study evaluates dendrimer-radioconjugates with Actinium-225 and low-dose cisplatin for treating metastatic triple negative breast cancer across different anatomical sites in mice, showing improved survival without long-term toxicity.

This study shows that systemic actinium-225 dendrimer-radioconjugates improve glioblastoma survival in mice, with enhanced efficacy when combined with temozolomide.

The paper addresses delivery heterogeneity in tumors by developing carrier cocktails that achieve spatial delivery uniformity through complementary delivery properties.