Functional profiling reveals a non-enzymatic role of NUDT5 in repressing purine de novo synthesis
Jung-Ming G. Lin, Anh Tuấn Nguyễn, Anne-Sophie M. C. Marques, Lorenzo Scrofani, Diana Daum, Ludwig G. Bauer, Carol Cheng, Luna D’Angelo, Juan Sánchez-Ávila, Christoph Bueschl, Pisanu Buphamalai, Marton I. Siklos, Jakob‐Wendelin Genger, Gerald Hofstätter, Kathrin Runggatscher, , Stefan Kubicek
The paper identifies a non-enzymatic role of NUDT5 in repressing purine de novo synthesis by scaffolding PPAT, with implications for cancer treatment and MTHFD1 deficiency.
bioRxiv · Mar 16, 2025 · PreprintMolecular Biology