Author

Anne-Sophie M. C. Marques

University of OxfordORCID 0009-0005-5726-508XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

K. HuberiD· 2 shared Ludwig G. BaueriD· 2 shared Stefan KubicekiD· 2 shared Alejandro Gonzalez Orta· 1 shared Andreas BergthaleriD· 1 shared Anh Tuấn NguyễniD· 1 shared Anna KoreniD· 1 shared Barr Tivon· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMolecular Biology

K. HuberORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMar 16, 2025

Functional profiling reveals a non-enzymatic role of NUDT5 in repressing purine de novo synthesis

Jung-Ming G. Lin, Anh Tuấn Nguyễn, Anne-Sophie M. C. Marques…·Stefan Kubicek

The paper identifies a non-enzymatic role of NUDT5 in repressing purine de novo synthesis by scaffolding PPAT, with implications for cancer treatment and MTHFD1 deficiency.

2 citations

humanexperimental assay

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Cell BiologybioRxivPreprintMar 16, 2025

Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity

Anne-Sophie M. C. Marques, Ludwig G. Bauer, Tuan Anh Nguyen…·K. Huber

The paper develops NUDT5 degraders and shows NUDT5 has a non-enzymatic role in 6-TG toxicity, distinct from NUDT15.

7 citations

humangenetic perturbation / CRISPR

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