Pharmacology & ToxicologybioRxivPreprint
Species Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with in Vivo Anti-alphaviral Activity
Mohammad Anwar Hossain, Abigail K. Mayo, Anirban Ghoshal…·Timothy Mark Willson
This study evaluates the species-dependent metabolism and pharmacokinetics of a covalent nsP2 protease inhibitor, showing rapid clearance in mice but antiviral efficacy, and suggests potential for human dosing.