Author

Kim L. R. Brouwer

University of North Carolina at Chapel HillORCID 0000-0003-1945-4929Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Abigail K. MayoiD· 1 shared Anirban GhoshaliD· 1 shared Ava M. VargasoniD· 1 shared Elizabeth J. AndersoniD· 1 shared Katia D. Pressey· 1 shared Mark T. HeiseiD· 1 shared Mohammad Anwar HossainiD· 1 shared Nathaniel J. MoormaniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Abigail K. MayoORCID

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1 paper

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintJan 13, 2025

Species Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with in Vivo Anti-alphaviral Activity

Mohammad Anwar Hossain, Abigail K. Mayo, Anirban Ghoshal…·Timothy Mark Willson

This study evaluates the species-dependent metabolism and pharmacokinetics of a covalent nsP2 protease inhibitor, showing rapid clearance in mice but antiviral efficacy, and suggests potential for human dosing.

DOI 10.1101/2025.01.13.632788

mousehuman

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