Ava M. Vargason

An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

The paper describes the enantioselective resolution of a chemical probe targeting CHIKV nsP2 helicase, showing potent antiviral activity for one enantiomer and low activity for the other.

Identification of Direct-acting nsP2 Helicase Inhibitors with Anti-alphaviral Activity

This paper identifies and optimizes oxaspiropiperidine inhibitors targeting nsP2hel, showing nanomolar antiviral activity against multiple alphaviruses.

Species Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with in Vivo Anti-alphaviral Activity

This study evaluates the species-dependent metabolism and pharmacokinetics of a covalent nsP2 protease inhibitor, showing rapid clearance in mice but antiviral efficacy, and suggests potential for human dosing.