Translational Fidelity Maintained by ZNF598-Dependent Ribosome Resolution Enables Cellular Adaptation to High Energy Demand
Toufic Kassouf, Laura Ryder, Katia El Ghoz, Bartosz Artur Kucharski, Lucile Dollet, Filip Dziaczkowski, Goda Snieckute, Sijie Chen, José Francisco Martı́nez, Dominika Malińska, Angel Loza‐Valdes, Małgorzata Alicja Śliwińska, Eric J. Bennett, Zachary Gerhart‐Hines, Simon Bekker‐Jensen, Grzegorz Sumara
This study identifies ZNF598 as a factor resolving translation stress during metabolic adaptation, showing its role in mitochondrial biogenesis and metabolic flexibility.
bioRxiv · Jan 27, 2026 · PreprintCell Biology